One Pot Protocol for the Synthesis of 6-amino-3-methyl-1,4- diphenyl-1,4-dihydropyrano[2,3-c]pyrazole carbonitrile derivatives

A series of 6-amino-3-methyl-1,4- diphenyl-1,4-dihydropyrano[2,3-c]pyrazole-5- carbonitrile derivatives was successfully synthesized through a one-pot, three-component reaction involving aromatic aldehydes, malononitrile, and 3- methyl-1-phenyl-2-pyrazolin-5-one. The reaction utilized NaOH: fly ash as a cost-effective and environmentally friendly catalyst in an aqueous medium. This approach demonstrated excellent catalytic efficiency, yielding products of high purity and an excellent yield. Key advantages of this methodology include a reduced environmental impact, low catalyst cost, and simple workup, making it a sustainable and practical synthetic strategy.