Research Article
Enhanced superior activity of imines-based metal(II) coordination complexes for vaccines perspectives
Beena Prajapati , Nand Kishor Bhagat , Deena Prasad Prajapati , Sampat Prasad Rawat
Published: December 1, 2025
Pages: pp. 119-122
Abstract
Article Summary
We report enhanced superior activity of
imines-based metal(II) coordination complexes of the
general type [Pd(L)2
] [where, HL = synthesized
bidentate ligand, M = Pd(II) (1), Cd(II) (2), Ni(II) (3)
and Cu(II) (4)] for vaccines perspectives. They exhibit
a distorted square planar geometry around the
metal(II) ions coordinated through the NS donor atoms
from their respective two deprotonated ligands HL.
DFT calculations were performed to validate the
experimental geometries and confirm the electronic
structures. In addition, the superior biological activity
(anticancer efficacy) were conducted against human
cell lines while molecular docking calculations were
employed to explore the antiviral potentials.
Keywords
Superior biological activity
metal(II) complexes
imine-based ligand
DFT
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Cite this Article
Prajapati, B., Bhagat, N., Prajapati, D., Rawat, S. (2025).
"Enhanced superior activity of imines-based metal(II) coordination complexes for vaccines perspectives".
Journal chemtracks,
27(1),
pp. 119-122.