Enhanced superior activity of imines-based metal(II) coordination complexes for vaccines perspectives

We report enhanced superior activity of imines-based metal(II) coordination complexes of the general type [Pd(L)2 ] [where, HL = synthesized bidentate ligand, M = Pd(II) (1), Cd(II) (2), Ni(II) (3) and Cu(II) (4)] for vaccines perspectives. They exhibit a distorted square planar geometry around the metal(II) ions coordinated through the NS donor atoms from their respective two deprotonated ligands HL. DFT calculations were performed to validate the experimental geometries and confirm the electronic structures. In addition, the superior biological activity (anticancer efficacy) were conducted against human cell lines while molecular docking calculations were employed to explore the antiviral potentials.