Environmentally Sustainable and Highly Effective Synthesis of Isoxazole Derivatives in Aqueous Solutions

A series of 5-arylisoxazole derivatives were prepared through the reaction of 3-(dimethylamino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in water, without the need for any catalysts. This approach offers several benefits, including simplified work-up procedures, mild reaction conditions, high yield, and an environmentally friendly process.