Synthesis of some isoxazole derivatives by ring transformation of pyrone-2

Heterocyclic compounds containing nitrogen and oxygen as hetero atoms are an important class of compounds largely employed in pharmaceutical and therapeutic field. The present paper deals with the synthesis of 3,5-disubstituted isoxazoles from substituted phenyl pyrone-2 on treatment with hydroxyl amine hydrochloride on irradiation in microwave. This method of ring transformation is a deviation from the classical synthetic procedures.